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Abstract #3757

NMR based metabolomic approach to study system responses of rat to tungsten exposure in multiple biological matrices

Ritu Tyagi 1 , Poonam Rana 1 , Mamta Gupta 1 , Deepak Bhatnagar 2 , Raja Roy 3 , and Subash Khushu 1

1 NMR Research centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DELHI, DELHI, India, 2 School of Biochemistry, Devi Ahilya Vishwavidayalaya, Indore, M.P., India, 3 Centre of Biomedical Magnetic Resonance (CBMR), Sanjay Gandhi Post Graduate of Medical Science Campus (SGPGI), Lucknow, U.P., India

Tungsten(W) is a complex metal that has numerous applications due to its tensile strength and high melting point. 1H NMR spectroscopy based study has been conducted on urine, liver and kidney extracts samples for identification of metabolite markers for W toxicity. Urine samples were collected at 8, 16, 24, 72 and 120h whereas tissue extracts were prepared for 24, 72 and 120h post dose for low, moderate and high doses of Na2WO4.2H2O. Spectral analysis showed dose dependent alterations in various metabolites associated with renal and hepatic toxicity and could be been seen as early as 8h post dose.

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