Abstract #3756
High resolution 1H NMR spectroscopy reveals acute changes in hippocampal metabolic physiology in a mouse model for cranial irradiation
Poonam Rana 1 , Mamta Gupta 1 , Ahmad Raza Khan 1 , B.S.Hemanth Kumar 1 , Raja Roy 2 , and Subash Khushu 3
1
NMR Research Centre, Institute of Nuclear
Medicine and Allied Sciences, Delhi, Delhi, India,
2
Centre
of Biomedical Magnetic Resonance, SGPGI Campus, Lucknow,
India,
3
Institute
of Nuclear Medicine and Allied Sciences, Delhi, India
Recently, hippocampal neurogenesis is shown to be
affected during acute phase of radiation exposure. To
understand the primary changes in hippocampus metabolism
during an acute phase of irradiation, proton NMR
spectroscopy was exploited on a mouse model for single
dose of 8 Gy cranial irradiation. In general, reduced
metabolic activity was observed in irradiated animals
compared with controls, typically evident in energy
metabolism, glutamine/glutamate and ketone bodies
metabolism. These changes provide strong evidence that
hippocampus is metabolically responsive to radiation
exposure. The changes observed in hippocampus metabolism
during acute phase might have long lasting effects on
cognitive development and function.
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