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Abstract #3756

High resolution 1H NMR spectroscopy reveals acute changes in hippocampal metabolic physiology in a mouse model for cranial irradiation

Poonam Rana 1 , Mamta Gupta 1 , Ahmad Raza Khan 1 , B.S.Hemanth Kumar 1 , Raja Roy 2 , and Subash Khushu 3

1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, Delhi, India, 2 Centre of Biomedical Magnetic Resonance, SGPGI Campus, Lucknow, India, 3 Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Recently, hippocampal neurogenesis is shown to be affected during acute phase of radiation exposure. To understand the primary changes in hippocampus metabolism during an acute phase of irradiation, proton NMR spectroscopy was exploited on a mouse model for single dose of 8 Gy cranial irradiation. In general, reduced metabolic activity was observed in irradiated animals compared with controls, typically evident in energy metabolism, glutamine/glutamate and ketone bodies metabolism. These changes provide strong evidence that hippocampus is metabolically responsive to radiation exposure. The changes observed in hippocampus metabolism during acute phase might have long lasting effects on cognitive development and function.

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