Abstract #3746
α-Fucose increased in the brain of Chronic Pelvic Pain Syndrome patients with inflammation at onset recorded by 2D L-COSY
Scott G Quadrelli 1 , Saadallah Ramadan 1 , Alexander Lin 2 , Jordan D Dimitrikov 3 , and Carolyn Mountford 1,2
1
Center for MR in Health, The University of
Newcastle, Newcastle, NSW, Australia,
2
Department
of Radiology, Center for Clinical Spectroscopy - Harvard
Medical School, Boston, MA, United States,
3
Department
of Nephrology, Childrens Hospital Boston and Harvard
Medical School, Boston, MA, United States
Chronic Pelvic Pain (CPPS) is a common, troubling and
poorly understood chronic pain condition affecting men.
This study aimed to characterise changes in free and
bound fucose in patients with CPPS using in vivo 2D
L-COSY at 3T. We report a statsically significant
increase in cross-peak volumes assigned to -fucose of
68%between healthy controls and patients with
inflammatory (type IIIB) CPPS. There is a concomitant
105% decrease in the assigned composite cross peak of
Thr/Fuc I suggesting an altered pathway.
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