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Abstract #3732

Examination of gradient-induced frequency drift on GABA-edited MRS

Ashley D Harris 1,2 , Benjamin Glaubitz 3 , Jamie Near 4 , C John Evans 5 , Nicolaas AJ Puts 1,2 , Tobias Schmidt-Wilcke 3 , Martin Tegenthoff 3 , Peter B Barker 1,2 , and Richard AE Edden 1,2

1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2 F.M. Kirby Research Centre, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Department of Neurology, BG-Klinikum Bergmannsheil, Ruhr - University, Bochum, Germany, 4 Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, PQ, Canada, 5 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom

The impact of gradient-induced frequency drift on GABA-edited MRS that occurs after a typical fMRI was assessed. Gradient-induced frequency drift has a significant impact on measured GABA. The primary source of measured GABA underestimation appears to be subtraction artifacts, which can largely be corrected with retrospective frequency correction. Gradient-induced frequency drift causes reduced editing efficiency of GABA but increased editing of macromolecules; therefore, consideration of protocol order or developing prospective frequency correction should also be considered.

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