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Abstract #3731

Towards pooling of neurochemical profiles obtained in the human brain at 3 T in a multi-site setting

Dinesh K Deelchand 1 , Isaac M. Adanyeguh 2,3 , Uzay E Emir 1,4 , Tra-My Nguyen 2 , Romain Valabregue 2,3 , Pierre-Gilles Henry 1 , Fanny Mochel 2,3 , and Glin z 1

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2 INSERM UMR S975, Brain and Spine Institute, Hospital La Salptrire, Paris, France, 3 University Pierre and Marie Curie, Paris, France, 4 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

In this work, we demonstrate that a wide range of metabolites (both singlet and J -coupled) can be quantified at two different sites with highly reproducible neurochemical profiles using an in-house developed and highly optimized semi-LASER sequence on clinical 3 T scanners. This will in turn allow pooling of data from multiple sites, which is particularly important for clinical research and clinical trials in rare diseases.

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