Abstract #3731
Towards pooling of neurochemical profiles obtained in the human brain at 3 T in a multi-site setting
Dinesh K Deelchand 1 , Isaac M. Adanyeguh 2,3 , Uzay E Emir 1,4 , Tra-My Nguyen 2 , Romain Valabregue 2,3 , Pierre-Gilles Henry 1 , Fanny Mochel 2,3 , and Glin z 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States,
2
INSERM
UMR S975, Brain and Spine Institute, Hospital La
Salptrire, Paris, France,
3
University
Pierre and Marie Curie, Paris, France,
4
FMRIB
Centre, Nuffield Department of Clinical Neurosciences,
University of Oxford, Oxford, United Kingdom
In this work, we demonstrate that a wide range of
metabolites (both singlet and
J
-coupled)
can be quantified at two different sites with highly
reproducible neurochemical profiles using an in-house
developed and highly optimized semi-LASER sequence on
clinical 3 T scanners. This will in turn allow pooling
of data from multiple sites, which is particularly
important for clinical research and clinical trials in
rare diseases.
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