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Abstract #3721

Detection of glutamate, glutamine, and glutathione by RF suppression and TE optimization at 7T

Li An 1 , Shizhe Li 1 , James B Murdoch 2 , Maria Ferraris Araneta 1 , Christopher Johnson 1 , and Jun Shen 1

1 National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 2 Toshiba Medical Research Institute USA, Mayfield Village, OH, United States

A PRESS pulse sequence inserted with a J-suppression RF pulse was optimized to resolve and measure glutamate, glutamine, and other metabolites such as glutathione at 7T. Phantom experiments were performed to validate results obtained from density matrix simulations. Metabolite concentration ratios were measured in the frontal lobe grey matter and white matter of eight healthy volunteers. Glutamate and glutamine concentrations were found to be significantly higher in the frontal lobe grey matter than in the frontal lobe white matter.

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