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Abstract #3695

Trans-catheter Perfusion MRI for Image-Guided Intraarterial Delivery of Therapeutic Agents to Target-Specific Brain Regions

Piotr Walczak 1,2 , Miroslaw Janowski 1,2 , Jeff WM Bulte 1,2 , and Monica Pearl 3

1 Radiology, Johns Hopkins University, Baltimore, MD, United States, 2 Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, United States, 3 Interventional Neuroradiology, Johns Hopkins University, Baltimore, MD, United States

Efficient delivery of therapeutics to the brain parenchyma is highly desired for several disciplines, including regenerative medicine and oncology. Advances in interventional neuroradiology enable safe, super-selective catheterization of small intracranial vessels; however, methods for predicting and optimizing the perfused parenchymal territory remain uninvestigated. We used DSC-enhanced trans-catheter perfusion MRI with Feraheme to predict the perfusion territory prior to intra-arterial (IA) injection of mannitol for blood brain barrier disruption and stem cell delivery. DSC perfusion MRI was highly predictive. This method may aid in improving the efficacy and safety of IA delivery of therapeutics.

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