Abstract #3667
Motion correction of high temporal 3T Dynamic Contrast Enhanced MRI of pancreatic cancer - preliminary results
R. Klaassen 1,2 , O. J. Gurney-Champion 3 , E. G.W. ter Voert 4 , A. Heerschap 4 , M. F. Bijlsma 2 , M. G.H. Besselink 5 , G. van Tienhoven 6 , C. Y. Nio 3 , J. Stoker 3 , C. J.A. Punt 1 , J. W. Wilmink 1 , H. W.M. van Laarhoven 1 , and A. J. Nederveen 3
1
Department of Medical Oncology, Academic
Medical Center - University of Amsterdam, Amsterdam,
Netherlands,
2
Department
of Experimental Oncology and Radiation Biology, Academic
Medical Center - University of Amsterdam, Amsterdam,
Netherlands,
3
Department
of Radiology, Academic Medical Center - University of
Amsterdam, Amsterdam, Netherlands,
4
Department
of Radiology, Radboud University Nijmegen Medical
Centre, Nijmegen, Netherlands,
5
Department of
Surgery, Academic Medical Center - University of
Amsterdam, Amsterdam, Netherlands,
6
Department
of Radiation Oncology, Academic Medical Center -
University of Amsterdam, Amsterdam, Netherlands
Breathing and peristaltic motions make reliable
quantification of DCE-MRI of the pancreas difficult.
Here we present an approach to minimize the effects of
movement on the quantification of DCE-MRI of the
pancreas. Three patients with proven pancreatic cancer
were scanned with our 3T DCE-MRI protocol. Images at
expiration were selected and registered. Quantification
was performed with a two compartment model. Ktrans maps
after motion correction showed better correlation with
anatomical structures. A larger patient group will show
if motion correction favours the capability of DCE-MRI
to discriminate between tumour and healthy tissue and if
it increases reproducibility between scans.
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