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Abstract #3616

Longitudinal patterns of diffusion measures in children treated for B-cell Lymphoma

John O Glass 1 , Emily M Paulus 1 , Zoltan Patay 2 , John T Sandlund 3 , and Wilburn E Reddick 1

1 Division of Translational Imaging Research, St. Jude Children's Research Hospital, Memphis, TN, United States, 2 Division of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 3 Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

This study examined the white matter (WM) integrity of 19 pediatric mature B-cell lymphoma patients without clinical signs or symptoms of neurotoxicity at five time points during treatment using fractional anisotropy (FA) and radial diffusion. FA from a defined region of interest was plotted for each patient, and two distinct patterns were found. Eleven patients showed a decrease in FA followed by a slow return toward baseline, consistent with demylination / remylination. Eight patients demonstrated an immediate spike in FA followed by a return to normal appearing development, possibly explained by restricted diffusion related to steroid therapy.

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