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Abstract #3615

Whole-body Imaging of Adipose Tissues in Mouse at 9.4T

Patrick J Bolan 1 , Amrutesh Puranik 2 , John W Osborn Jr. 3 , Maria Razzoli 3 , Alessandro Bartolomucci 3 , Pu Tzu Liu 4 , Yi-Wei Lin 4 , and Li-Na Wei 4

1 Radiology - CMRR, University of Minnesota, Minneapolis, Minnesota, United States, 2 Mayo Clinic, Rochester, MN, United States, 3 Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States, 4 Pharmacology, University of Minnesota, Minneapolis, MN, United States

This work demonstrates anatomic and parametric water-fat imaging of adipose tissues in post mortem mice at 9.4 T with spatial resolution (156 m isotropic) substantially higher than previous studies. Anatomic and fat fraction images were used to segment different adipose tissue compartments (e.g., visceral vs. subcutaneous); fat fraction and R2* maps were used to distinctly identify brown adipose tissue depots. This approach is applicable for finely-segmented quantitative volumetry of brown and white adipose tissue depots.

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