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Abstract #3596

MRI based Noninvasively Differentiation between Aggregated and Dispersed Liver Iron in vivo: a feasibility study

Arthur Peter Wunderlich 1 , Markus Juchems 1 , Holger Cario 2 , Matthias Weigel 3 , and Meinrad Beer 1

1 Dept. for Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Germany, 2 Pediatry, Univ.-Clinic Ulm, Ulm, Germany, 3 Radiological Physics, University of Basel Hospital, Basel, Switzerland

A method previously described by Jensen et al. was implemented and tested in a clinical setting. 20 patients suspected for liver iron overload were scanned by MRI using spin-echo (SE) and multi-contrast spin-echo (MC-SE) sequences. Data of MC-SE were fitted to theory to get tissue parameters which are hypothesized to allow a differentiation between aggregated and dispersed liver iron. The two parameters in question were correlated to liver iron content (LIC) determined from SE sequences. Only the aggregation index A correlated positively to LIC. The other parameter reduced transverse relaxation rate RR2 showed no significant correlation to LIC.

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