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Abstract #3595

The Importance of consistent RF Spoiling for MRI based Liver Iron Content Determination with Signal Intensity Ratios preliminary data

Arthur Peter Wunderlich 1 , Volker Rasche 2,3 , Holger Cario 4 , Markus Juchems 1 , and Meinrad Beer 1

1 Dept. for Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Germany, 2 Experimental Cardiovascular Imaging, Univ.-Clinic Ulm, Ulm, Germany, 3 Internal Medicine II, Univ.-Clinic Ulm, Ulm, Germany, 4 Pediatry, Univ.-Clinic Ulm, Ulm, Germany

Signal Intensity Ratio (SIR) between liver and reference tissue (paraspinal muscle) has proven to be a reliable method for determination of liver iron content (LIC). However, we found that SIR values depend on activation of RF spoiling. In a preliminary analysis, we determined LIC with the method published by Gandonin data with and without RF spoiling and compared these values to LIC determined from the commercial Ferriscan method. Linear correlation between both methods was performed and R was evaluated. While we achieve a good R value without RF spoiling, it was significantly worse with RF spoiling.

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