Meeting Banner
Abstract #3588

Fat Quantification in Chronic Liver Disease Patients with 3D Multi-Echo GRE Dixon at 1.5 T: Comparison with T2 Corrected Spectroscopy

Liana Guerra Sanches-Rocha 1 , Ludmila Ribeiro 1 , Karine Minaif Martins 2 , Ralph Markus Strecker 3 , Xiadong Zhong 4 , Stephan Kannengiesser 5 , and Ronaldo Hueb Baroni 2

1 Imaging, Albert Einstein Hospital, So Paulo, So Paulo, Brazil, 2 Imaging, Albert Einstein Hospital, So Paulo, Brazil, 3 Siemens Ltda, So Paulo, Brazil, 4 MR R&D Collaborations, Siemens Healthcare MR R&D Collaborations, Georgia, United States, 5 MR R&D Collaborations, Siemens Medical Solutions, Germany

The fat fraction measure using magnetic resonance imaging has been highly accurate alternative method to the biopsy procedure. The spectroscopy has been used as accurated methodology to access and monitor liver steatosis. The method had some of it's problem solved with the T2 correction in a fast aquisition (HISTO). In this study, we aimed to validate against the HISTO spectroscopy, a new 6-echoes-gradient-echo sequence, that uses a hybrid magnitude/complex data algorithm, including correction for T1 bias and T2* decay, and multipeak fat spectrum, that already has been validated at 3T system, at a clinical wide -bore 1,5T system. We evaluated 69 sets from patients that are waiting for liver transplantation and had undergone abdominal MRI. The fat percentage result from inline HISTO report and the proton density fat fraction (PDFF) obtained from the map generate inline from the new sequence were correlated. The intraclass correlation coefficient (ICC) between both sequenceswas 0,830 (CI95%=0,737 to 0,891) for fat percentage . We conclued that the new sequence, with multipeak fat spectral modeling and six-echo chemical shift encoding, has a good correlation with HISTO spectroscopy in the PDFF for chronic liver disease patients at 1,5T.

This abstract and the presentation materials are available to members only; a login is required.

Join Here