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Abstract #3587

Impact of inversion-recovery fat suppression on hepatic R2* quantitation in transfusional siderosis.

Antonella Meloni 1,2 , J. Michael Tyszka 3 , Alessia Pepe 1 , Massimo Lombardi 1 , and John C Wood 2,4

1 CMR Unit, Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy, 2 Department of Pediatrics, Division of Cardiology, Childrens Hospital Los Angeles, Los Angeles, California, United States, 3 Division of Biology, California Institute of Technology, Pasadena, California, United States, 4 Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, California, United States

This represents the first study to compare the impact of fat saturation prepulse on R2* quantitation in transfusional siderosis. We demonstrate that SPIR fat suppression systematically lowered R2* estimates by 3.9% 7.0, and introduced comparable random uncertainty between the two measurements. Since calibration curves have been derived using non-fat saturated images, these biases should be corrected when reporting LIC values from fat saturated images.

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