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Abstract #3576

Magnetic Resonance Imaging Evaluation of the Adaptive Response of the Contralateral Kidney Following Nephrectomy in Patients with Renal Cell Carcinoma

Mao-Yuan Marine Su 1 , Kuo-How Huang 2 , Chin-Chen Chang 1 , Vin-Cent Wu 3 , Wen-Chau Wu 4 , Kao-Lang Liu 1 , and Wen-Yih Isaac Tseng 1,5

1 Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 2 Department of Urology, National Taiwan University Hospital, Taipei, Taiwan, 3 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 4 Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, 5 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

This study aimed to evaluate the adaptive responses of the contralateral kidney in patients with renal cell carcinoma (RCC) following radical nephrectomy (RN). Eleven patients with RCC scheduled for RN and 15 control patients scheduled for adrenalectomy (Control) were prospectively studied. All the subjects underwent 4 MRI studies: 1 before surgery and 3 at 1 week, 1 month and 3 months after surgery, respectively. Our results indicated that RN in patients with RCC results in an early increase in renal blood flow (RBF) of the contralateral kidney. At 3 months, the patients showed normalization of the RBF, accompanied by compensatory renal hypertrophy. In patients with reduced renal mass, an early increase in RBF was associated with late renal hypertrophy. Therefore, given healthy conditions of the kidneys at baseline, we might be able to predict the late renal function of the contralateral kidney based on its early response to RBF.

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