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Abstract #3575

Computed Diffusion-Weighted MR Imaging for Prostate Cancer Detection: Optimization of b-Value Combinations for Generating High b-Value Images.

Yoshiko Ueno 1 , Satoru Takahashi 1 , Kazuhiro Kitajima 1 , Yu Ueda 2 , Masamori Kassai 3 , Masao Yui 3 , Yoshiharu Ohno 1,4 , and Kazuro Sugimura 1

1 Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan, 2 Division of Radiology, Kobe University Hospital, Kobe, Hyogo, Japan, 3 MRI Systems Development Department, Toshiba Medical Systems Corp., Otawara, Tochigi, Japan, 4 Advanced Biomedical Imaging Research, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

Computed DWI (cDWI) is proposed as a new technique that produces any b-value images from DWIs acquired with at least two different b-values. However, it remains unclear which combination of b-values is optimal for generating high-b-value images. We hypothesize that appropriate b value selection for cDWI can improve image quality and detection capability on cDWI as compared with actual DWI with ultra-high b value. The aim of this study was to determine the appropriate b-value combination for generating cDWI at b=2000 s/mm 2 to improve prostate cancer detection, when compared with actual DWI at b=2000 s/mm 2 on a 3T MR system.

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