Abstract #3569
ASL and BOLD MRI Measurements in Human Kidneys
Jon Thacker 1 , Huan Tan 2 , Lu-Ping Li 3,4 , Wei Li 3 , Stuart Sprague 4,5 , Orly Kohn 6 , Ivana Lazich 6 , and Pottumarthi V Prasad 3,4
1
Northwestern University, Evanston, IL,
United States,
2
Department
of Surgery, University of Chicago, IL, United States,
3
Department
of Radiology, Northshore University HealthSystem, IL,
United States,
4
The
University of Chicago Pritzker School of Medicine, IL,
United States,
5
Division
of Nephrology, Northshore University HealthSystem, IL,
United States,
6
Section
of Nephrology, The University of Chicago Pritzker School
of Medicine, IL, United States
In this study we sought to assess if there was a
correlation between arterial spin labeled perfusion and
blood oxygen level dependent oxygenation measurements in
healthy subjects and patients with chronic kidney
disease (CKD). We found that there was no significant
correlation between the two, suggesting that, unlike
most organs, renal oxygenation is not determined by
blood flow. Additionally we found a significant R2*
change in healthy subjects renal medulla between
baseline and furosemide challenge. No significant change
in R2* was observed in other regions or CKD patients.
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