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Abstract #3567

How does renal function change with nephrectomy? Initial experience using renal blood flow measured by arterial spin labelling MRI combined with 51Cr-EDTA filtration (GFR) to calculate renal filtration fraction

Marica Cutajar 1 , David L Thomas 2 , Tina Banks 3 , Christopher A Clark 1 , and Isky Gordon 1

1 Imaging and Biophysics, UCL, Institute of Child Health, London, London, United Kingdom, 2 Department of Brain Repair and Rehabilitation, UCL, Institute of Neurology, London, London, United Kingdom, 3 Department of Radiology, Great Ormond Street Hospital, London, London, United Kingdom

This study is the first to measure renal plasma flow (RPF) non-invasively in kidney donors before and after donation. RPF obtained using Arterial Spin Labelling MRI combined with 51Cr-EDTA filtration (GFR) was used to calculate renal filtration fraction and hence assess the effect of nephrectomy on renal function. 7 healthy kidney transplant donors underwent two MRI scans (without the use of exogenous contrast agents) as well as multiple blood samples 51Cr-EDTA, prior to nephrectomy and one year after donation. We found that GFR increased more than RPF hence causing the FF to increase.

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