Abstract #3536
Age-Dependent Changes in Alveolar Microstructure of Healthy Adults by in vivo Lung Morphometry with Hyperpolarized 3He Diffusion MRI
James D Quirk 1 , Jason C Woods 2 , Alexander L Sukstanskii 1 , Barbara A Lutey 3 , Mario Castro 3 , and Dmitriy A Yablonskiy 1
1
Mallinckrodt Institute of Radiology,
Washington University School of Medicine, St. Louis, MO,
United States,
2
Pediatrics
and Radiology, Cincinnati Children's Hospital,
Cincinnati, OH, United States,
3
Pulmonary
and Critical Care Medicine, Washington University School
of Medicine, St. Louis, MO, United States
Pulmonary function in adults is known to decline with
age. Using non-invasive diffusion MRI-based in vivo
helium-3 lung morphometry, we studied 38 healthy
subjects (ages 18-70) to determine the changes in lung
microstructure at the alveolar level associated with
this decline. We found that with increased age, there is
a significant decrease in alveolar density, associated
with both an increase in acinar duct lumen and acinar
duct radius and a decrease in the alveolar depth. This
establishes a baseline of age-dependent lung parameters
for use in future studies to detect changes associated
with pulmonary diseases.
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