Abstract #3535
Comparison of Calculated Specific Ventilation using the 'Wash-in' and 'Wash-out' Hyperpolarized 3 He MRI Techniques
Sarmad Siddiqui 1 , Mehrdad Pourfathi 1 , Hooman Hamedani 1 , Yi Xin 1 , Hoora Shaghaghi 1 , Stephen J. Kadlecek 1 , and Rahim R. Rizi 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States
It has been previously demonstrated that hyperpolarized
(HP) 3He MRI can be used to construct regional
fractional ventilation maps by imaging HP signal build
up, by delivering several HP breaths, each followed by a
breath hold for image acquisition. More recently, it was
shown [2] that a similar regional fractional ventilation
map could be constructed by fitting the signal decay
after only one inhalation of HP gas. In this study, we
compare the regional fractional ventilation maps
generated by both the wash-in and wash-out methods
to determine the robustness of the wash-out method
compared to the wash-in method.
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