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Abstract #3498

Longitudinal monitoring of transverse relaxation time changes in the corpus callosum of a mouse model of Alzheimers disease

Firat Kara 1,2 , Reinhard Schliebs 3 , Stephan Roner 3 , Annemie van der Linden 1 , Huub J.M. Groot 2 , and A. Alia 2,4

1 Bio-imaging Lab, Biomedical Sciences, University of Antwerp, Antwerp, Belgium, 2 Leiden Institute of Chemistry, Gorlaeus Laboratoria, Leiden University, Leiden, Netherlands, 3 Paul Flechsig Institute for Brain Research, Leipzig University, Leipzig, Germany, 4 Institute of Medical Physics and Biophysics, Leipzig University, Leipzig, Germany

In this longitudinal study, we monitored in vivo magnetic resonance transverse relaxation time (T2) changes in the corpus callosum of the Tg2576 mouse model of Alzheimer's disease at 10, 12, 16, and 18 months of age. Our results showed significant elongation of in vivo T2 values in the corpus callosum of Tg2576 mice compared to wild-type mice at all studied ages. Our results suggest that demyelinating and inflammatory pathology may lead to prolonged relaxation times and can mark an early event during AD progression. To our knowledge, this is the first longitudinal in vivo T2 study assessing microstructural changes in the CC of the Tg2576 mice.

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