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Abstract #3452

Serial Assessment of Spinal Cord Injury in Monkeys by Multi-parametric MRI at 9.4T

Feng Wang 1,2 , Zhongliang Zu 1,2 , Huixin Qi 3 , Chaohui Tang 1 , John C. Gore 1,2 , and Li Min Chen 1,2

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2 Radiology Department, Vanderbilt University, Nashville, TN, United States, 3 Psychology Department, Vanderbilt University, TN, United States

Multi-parametric MRI methods such as chemical exchange saturation transfer (CEST), magnetization transfer (MT) and diffusion weighted imaging were applied to characterize spinal cord injuries (SCI) and their progression over time in anesthetized squirrel monkeys up to 24 weeks after unilateral dorsal column lesion (C4-C5). These methods are sensitive to the molecular and cellular composition of tissues. Other than the unusual high ADC and low MTR values observed for abnormal volume (AV) around the lesion site in spinal cord, significant variations of MTRasym were also observed for AV at RF offsets ~3.5, 2.2 and 1.0 ppm after lesion for the first time.

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