Meeting Banner
Abstract #3451

High-resolution, single-point, quantitative magnetization transfer (qMT) of the human spinal cord: application and validation in patients with MS

Alex K Smith 1,2 , Richard D Dortch 2,3 , Lindsey M Dethrage 2 , and Seth A Smith 2,3

1 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

The spinal cord is responsible for mediating neurological function between the brain and peripheral nervous system, and is involved in many diseases such as MS. Quantitative MRI can probe tissue microstructure, but technical hurdles exist in the spinal cord due to its small size and constant motion. qMT has been reported to be sensitive to myelin changes, and has been studied extensively in the brain, but suffers from long scan times. Utilizing a single-point qMT methodology in the cervical spinal cords of patients with MS, we derived indices reflective of myelination that we show are abnormal compared to healthy controls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here