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Abstract #3432

Abnormal intrinsic brain activity in temporomandibular disorder with centric relation-maximum intercuspation discrepancy: a resting state functional MRI study

Fei Li 1 , Shushu He 2 , Ning He 3 , Xiaoqi Huang 1 , Su Lui 1 , Qiyong Gong 1 , and Song Chen 2

1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 State Key Laboratory of Oral Disease, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China, 3 Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, China

Temporomandibular disorders (TMD) is a chronic pain disorder characterized by pain in the masticatory muscles and temporomandibular joint. Functional occlusal theory considers centric relation-maximum intercuspation (CR-MI) discrepancy as a potential factor for TMD and believes that achieving CR-MI harmony after orthodontic treatment reduces the risk of development of TMD. Previous researches found TMD patients had abnormal cerebral function, however, there are few studies investigating the correlation between CR-MI discrepancy characteristics and intrinsic cerebral function. The present study aimed to explore abnormal brain function in TMD patients with CR-MI discrepancy relative to healthy controls using resting state functional MRI.

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