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Abstract #3409

Simultaneous Quantification of Permeability and Perfusion in Multiple Sclerosis Lesions

Govind Nair 1 , Katherine C Gao 1 , Colin D Shea 1 , Souheil J Inati 1 , Luca Massacesi 2 , and Daniel S Reich 1

1 NINDS, National Institutes of Health, Bethesda, MD, United States, 2 Neuroscience, Careggi University hospital, University of Florence, Florence, Florence, Italy

The permeability and perfusion characteristics of MS lesions change over time, as most acute enhancing lesion stop enhancing in about 2 months. This cross-sectional study used a double-echo T1-weighted gradient-echo EPI sequence to simultaneously quantify perfusion and permeability parameters in 16 MS patients. Eighteen percent of the lesions studied had non-zero permeability, even when no enhancement was appreciated in the post-contrast T1-weighted images. These lesions had a smaller plasma fraction compared to enhancing lesions, suggesting longer lasting and more varying dynamic changes to vasculature within lesions than previously understood.

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