Abstract #3408
Functional relevance of cortical diffusion alterations in multiple sclerosis
Afaf S Elsarraj 1 , Daniel Rodriguez Gutierrez 1 , Hamza Alshuft 1 , Cris S Constantinescu 2 , Dorothee P Auer 1 , and Robert A Dineen 1
1
Radiological Sciences, Division of Clinical
Neurosciences, University of Nottingham, Nottingham,
United Kingdom,
2
Clinical
Neurology Group, Division of Clinical Neurosciences,
University of Nottingham, Nottingham, United Kingdom
Measurement of proton diffusion properties provides a
potential means to quantify cortical pathology in
multiple sclerosis (MS). We test the functional
relevance of cortical ultrastructure as measured by mean
diffusivity (MD) in MS. We perform cortical
surface-based mapping of partial volume corrected MD for
a cohort of 40 MS patients, with vertex-wise correlation
between MD and measures of clinical and cognitive
performance. Our results show statistically significant
differential patterns of functionally-relevant regional
cortical diffusion elevation between performance
measures in different functional domains in MS.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
