Abstract #3406
Tract-specific q-space imaging of the cervical cord demonstrates early axonal damage in primary progressive multiple sclerosis
Khaled Abdel-Aziz 1 , Torben Schneider 1 , Marios C Yiannakas 1 , Daniel Altmann 1 , Claudia A.M Wheeler-Kingshott 1 , Amy L Peters 2 , Brian L Day 2 , Alan J Thompson 1,3 , and Olga Ciccarelli 1,3
1
NMR Research Unit, Queen Square MS Centre,
UCL institute of neurology, London, Greater London,
United Kingdom,
2
Sobell
Department, UCL institute of neurology, London, Greater
London, United Kingdom,
3
NIHR
UCLH-UCL Biomedical Research Centre (BRC), London,
United Kingdom
Q-space imaging (QSI) is a model free diffusion weighted
imaging technique sensitive to changes within lesions
and normal appearing white matter in multiple sclerosis.
By applying tract-specific QSI to the cervical spinal
cord of patients with early primary progressive multiple
sclerosis (PPMS) we have demonstrated increased
perpendicular diffusion in the cervical cord suggesting
the loss of axons and/or myelin barriers to diffusion in
the perpendicular direction. These changes correlated
with clinical scales of disability. Our results suggest
spinal cord QSI is a sensitive method for detecting
early pathological changes in early PPMS that are
associated with clinical disability
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