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Abstract #3405

Hypoperfusion of thalami is correlated with disability in MS patients - A statistical mapping analysis of whole brain pseudo-continuous arterial spin labeling MRI

Emilie Doche 1,2 , Angle Lecocq 1,3 , Adil Maarouf 1,3 , Guillaume Duhamel 1,3 , Virginie Callot 1,3 , Elisabeth Soulier 1,3 , Sylviane Confort-Gouny 1,3 , Audrey Rico 1,2 , Franoise Reuter 1,2 , Bertrand Audoin 1,2 , Jean Pelletier 1,2 , Jean-Philippe Ranjeva 1,3 , and Wafaa Zaaraoui 1,3

1 Aix-Marseille Universit, CNRS CRMBM UMR 7339, Marseille, France, 2 Pole de Neurosciences Cliniques, APHM Hopital de la Timone, Marseille, France, 3 Pole d'Imagerie mdicale, CEMEREM, APHM Hopital de la Timone, Marseille cedex 5, France

Increasing evidence suggests a microvascular participation in Multiple Sclerosis (MS) injury, but relationships between brain perfusion abnormalities and disability have not been clearly demonstrated. Brain perfusion of 23 MS patients and 16 healthy subjects was assessed non-invasively by pseudoContinuous Arterial Spin Labeling MRI at 3T. Cerebral blood flow (CBF) of gray matter, white matter and T2lesions were extracted and voxelwise analyses of CBF abnormalities were performed. Perfusion abnormalities were found in T2lesions and in the thalamus in MS patients (SPM8, t-test p<0.005, k=20 FDR corrected p<0.05), and correlated to disability (p=0.014, rho=-0.507).

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