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Abstract #3403

Investigation of Susceptibility Contrast in Grey and White Matter Multiple Sclerosis Lesions

Cynthia Wisnieff 1,2 , Ryan Brown 3 , David Pitt 4 , and Yi Wang 1,2

1 Biomedical Engineering, Cornell University, Ithaca, New York, United States, 2 Radiology, Weill Cornell Medical College, New York, New York, United States, 3 Radiology, New York University, New York, New York, United States, 4 Neurology, Yale University, New Haven, Connecticut, United States

This work examines the susceptibility properties of ex vivo MS brain specimens with quantitative susceptibility mapping (QSM). QSM reveals the diamagnetic properties of cortical lesions and increased paramagnetic properties of white matter lesions. Changes in both white matter and grey matter tissue properties are linked to the pathogenic process in multiple sclerosis (MS). This preliminary data demonstrates the ability of QSM to detect WM and GM lesions compared to other gradient echo based methods and assesses changes in susceptibility within both white matter and grey matter lesions compared to normal appearing tissue.

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