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Abstract #3402

How Important is the Effect of Lesion In-painting on Regional Atrophy in Multiple Sclerosis?

Sushmita Datta 1 , Terrell D. Staewen 1 , Stacy S. Cofield 2 , Gary R. Cutter 2 , Fred D. Lublin 3 , Jerry S. Wolinsky 4 , and Ponnada A. Narayana 1

1 Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston, Houston, TX, United States, 2 Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States, 3 The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York City, New York, United States, 4 Neurology, The University of Texas Health Science Center, Houston, TX, United States

The effect of lesion in-painting on the estimated regional atrophy in multiple sclerosis (MS) was evaluated on a large cohort for different T2 lesion burdens. The results suggest that in-painting has effects on regions close to the ventricular regions. The effect is most prominent at high lesion burden.

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