Combined use of diffusion MRI and visual evoked potentials to assess visual abnormalities in Multiple Sclerosis.
Mariko Yoshida 1 , Masaaki Hori 1 , Kazumasa Yokoyama 2 , Nozomi Hamasaki 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Kohei Kamiya 1 , Shigeki Aoki 1 , Yoshitaka Masutani 3 , and Nobutaka Hattori 2
Department of Radiology, Juntendo University
School of Medicine, Bunkyo, Tokyo, Japan,
of Neurology, Juntendo University School of Medicine,
of Radiology and Biomedical Engineering, Graduate School
of Medicine, The University of Tokyo, Tokyo, Japan
Visual disability is common in multiple sclerosis (MS).
We investigated changes in diffusion MRI metrics,
including the diffusional kurtosis parameter, in the
optic tract and radiations comparing optic nerve damage
in visual evoked potentials (VEPs).Twenty-one patients
with MS participated in this study. We compared the
degree of diffusional abnormalities in the optic tract
and radiations between MS patients with bilateral and
unilateral optic damage. We showed that unilateral
damages in the pregeniculate optic pathway were
adequately compensated for by the lateral geniculate
nucleus owing to neural plasticity. Moreover, we
confirmed correlations between diffusion MRI metrics and
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