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Abstract #3397

Combined use of diffusion MRI and visual evoked potentials to assess visual abnormalities in Multiple Sclerosis.

Mariko Yoshida 1 , Masaaki Hori 1 , Kazumasa Yokoyama 2 , Nozomi Hamasaki 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Kohei Kamiya 1 , Shigeki Aoki 1 , Yoshitaka Masutani 3 , and Nobutaka Hattori 2

1 Department of Radiology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan, 2 Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, 3 Division of Radiology and Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Visual disability is common in multiple sclerosis (MS). We investigated changes in diffusion MRI metrics, including the diffusional kurtosis parameter, in the optic tract and radiations comparing optic nerve damage in visual evoked potentials (VEPs).Twenty-one patients with MS participated in this study. We compared the degree of diffusional abnormalities in the optic tract and radiations between MS patients with bilateral and unilateral optic damage. We showed that unilateral damages in the pregeniculate optic pathway were adequately compensated for by the lateral geniculate nucleus owing to neural plasticity. Moreover, we confirmed correlations between diffusion MRI metrics and VEPs latency.

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