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Abstract #3394

Whole brain functional connectivity in clinically isolated syndrome with normal conventional brain MRI: a 5-year follow-up study

Yaou Liu 1 , Yunyun Duan 1 , Zhengjia Dai 2 , Ni Shu 2 , Yong He 2 , and Kuncheng Li 1

1 Xuanwu Hospital, Beijing, China, 2 Beijing Normal University, Beijing, China

We demonstrate both functional impairment and compensation in CIS, the earliest stage of MS, by voxel-based resting-state fMRI. Furthermore, from CIS to MS, the brain plasticity enhance especially in deep gray matter, thus the alterations in CIS may be transient prior to the onset of significant cortical reorganization. Increased FCS in REC/ OLF/ACC and MFG implies the brain reserve, which may predict the conversion to MS.

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