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Abstract #3393

Rapid and robust whole brain myelin water mapping in 6.5 minutes: Validation and clinical feasibility

Thanh D. Nguyen 1 , Kofi Deh 1 , Ashish Raj 1 , Susan A. Gauthier 2 , and Yi Wang 1

1 Radiology, Weill Cornell Medical College, New York, NY, United States, 2 Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, United States

Whole brain myelin water fraction (MWF) imaging is highly desired but currently is too time-consuming to be useful clinically, with acquisition times exceeding 10 minutes and processing times still on the order of hours. The purpose of this study is to develop and optimize a rapid and robust whole brain MWF mapping protocol for routine clinical use at 3T with 6.5 min acquisition and 15 min processing time. Results in healthy controls and MS patients demonstrate the feasibility of our approach.

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