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Abstract #3390

Cerebellar connectomics provide new biomarkers in early multiple sclerosis

David Romascano 1,2 , Djalel-Eddine Meskaldji 2 , Guillaume Bonnier 1 , Samanta Simioni 3 , David Rotzinger 4 , Ying-Chia Lin 5 , Gloria Menegaz 5 , Alexis Roche 4,6 , Myriam Schluep 3 , Renaud Du Pasquier 3 , Jonas Richiardi 7,8 , Dimitri Van De Ville 7,8 , Alessandro Daducci 2 , Tilman J. Sumpf 9 , Jens Frahm 9 , Jean-Philippe Thiran 2,4 , Gunnar Krueger 1,6 , and Cristina Granziera 1,3

1 CIBM-AIT, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 2 Signal Processing Laboratory (LTS5), cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 3 Department of Clinical Neurosciences, CHUV and UNIL, Lausanne, Switzerland, 4 Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 5 Department of Computer Science, University of Verona, Verona, Italy, 6 Advanced Clinical Imaging Technology, Siemens Healthcare IM BM PI, Lausanne, Switzerland, 7 School of Engineering, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 8 Department of Radiology and Medical Informations, University of Geneva, Geneva, Switzerland, 9 Biomedizinische NMR Forschungs GmbH, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany

The cerebellum is involved in multiple sclerosis (MS), but its implication in early phases is still poorly understood. We investigated structural and functional cerebellar connectivity alterations in early and minimally impaired MS patients, and their correlation to patients clinical status. We reconstructed the connectomes of 28 MS patients and 16 healthy controls and performed network statistical analysis. Structural connectivity was found to be altered independently from cerebellar lesion count, volume and disease duration; the microstructural properties of altered connections correlated with patients motor and cognitive performance. No topological reorganization or compensatory mechanisms were observed at this stage.

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