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Abstract #3389

Changes in "Pseudo T2" Correlate with Brain Volume Changes Induced by Dehydration and Rehydration: Toward Detection and Correction of Edema Effects on Brain Atrophy Measurements

Robert Allan Brown 1 , Kunio Nakamura 1 , David Araujo 1 , Sridar Narayanan 1 , and Douglas Arnold 1

1 Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

Brain volume (BV) can change in response to hydration status. It has been hypothesized that some decreases in BV seen in response to treatment may be due to the resolution of edema (pseudoatrophy). We scanned subjects after both dehydration and rehydration and determined a quantitative relationship between changes in two-point T2 measurements and brain volume. This can be used to investigate pseudoatrophy as well as correct brain volume measurements for hydration status.

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