Changes in "Pseudo T2" Correlate with Brain Volume Changes Induced by Dehydration and Rehydration: Toward Detection and Correction of Edema Effects on Brain Atrophy Measurements
Robert Allan Brown 1 , Kunio Nakamura 1 , David Araujo 1 , Sridar Narayanan 1 , and Douglas Arnold 1
Montreal Neurological Institute, McGill
University, Montreal, Quebec, Canada
Brain volume (BV) can change in response to hydration
status. It has been hypothesized that some decreases in
BV seen in response to treatment may be due to the
resolution of edema (pseudoatrophy). We scanned subjects
after both dehydration and rehydration and determined a
quantitative relationship between changes in two-point
T2 measurements and brain volume. This can be used to
investigate pseudoatrophy as well as correct brain
volume measurements for hydration status.
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