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Abstract #3378

Quantification of GABA in the grey matter in Multiple Sclerosis

Niamh Cawley 1 , Bhavana Solanky 2 , Nils Muhlert 3 , CAM Wheeler-Kingshott 2 , A.J Thompson 1,4 , and Olga Ciccarelli 1,5

1 Dept. Brain Repair & Rehabilitation, QS MS Centre, UCL Institute of Neurology, London, United Kingdom, 2 Department of Neuroinflammation, QS MS Centre, UCL Institute of Neurology, London, United Kingdom, 3 Cognitive Neuroscience, Cardiff, United Kingdom, 4 NIHR UCL-UCLH Biomedical Research Centre, London, United Kingdom, 5 NIHR UCL-UCLH Biomedical Reserach Centre, London, United Kingdom

In this study we have provided quantification of GABA concentration in the hippocampus, prefrontal cortex and sensorimotor cortex in patients with secondary progressive MS in comparison to healthy controls using the MEGA-PRESS 1H MRS at 3T. Patients showed reduced [GABA+] levels in the hippocampus and in the sensori-motor cortex, compared to controls. We then looked to see if [GABA+] was associated with cognitive impairment in the hippocampus and motor and sensory function in the sensori-motor cortex. There was a significant association between grip strength and [GABA+] in the sensori-motor cortex as well as muscle strength using the MRC scoring system.

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