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Abstract #3377

Towards Pathoneurochemical Profiling of Multiple Sclerosis: Single-Session Measurement of Glutathione, GABA and Glutamate with MR Spectroscopy at 7 Tesla

Hetty Prinsen 1 , Robin A de Graaf 1 , Graeme F Mason 1 , Daniel Pelletier 1 , and Christoph Juchem 1

1 Yale University, New Haven, CT, United States

Glutathione (GSH), GABA, and glutamate are assumed to play key roles in the onset and progression of multiple sclerosis (MS). We report their measurement in a single 1-hour session establishment of J-difference editing and STEAM MR spectroscopy (MRS) twice in five healthy individuals and once in an MS patient (along with other MS-relevant neurochemicals such as NAA, myo-inositol, creatine, and cholines). The implementation is expected to serve as a tool for clinical MS research, patient monitoring, and treatment control.

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