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Abstract #3365

Lactate detection in non-enhancing brain of patients with Glioblastoma Multiforme using selective multiple quantum filtered CSI

Lisa M Harris 1 , Nina Tunariu 1 , Christina Messiou 1 , Toni Wallace 1 , Julie Hughes 1 , Nandita M deSouza 1 , Martin O Leach 1 , and Geoffrey S Payne 1

1 CRUK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom

Glioblastoma multiforme (GBM) is an aggressive brain tumour, active tumour potentially goes unrecognized as it may invade further than is visible on standard MRI. Recognition of tumoral infiltration extent potentially could improve treatment outcome. This study presents work applying a selective homonuclear multiple quantum coherence transfer (SelMQC) sequence in a group of GBM tumours to assess lactate concentration. Lactate was seen in the surrounding tissue of some patients, all of whom had recently completed radiotherapy. Two conclusions could be possible, either the surrounding lactate is from infiltrating tumour or lactate in the periphery maybe an effect of radiation induced hypoxia.

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