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Abstract #3308

Isolation of CEST contrasts from asymmetric MT effects in a human brain

Jae-Seung Lee 1,2 , Ding Xia 1 , Yulin Ge 1 , Alexej Jershow 2 , and Ravinder Regatte 1

1 Radiology, New York University, New York, NY, United States, 2 Chemistry, New York University, New York, NY, United States

Chemical exchange saturation transfer (CEST) has great potential to enhance the detection of exchangeable proton species such as low concentrations of metabolites in vivo brain. However, CEST effects are often masked by asymmetric magnetization transfer (MT) effects from macromolecules in tissues and organs. Here, we show that the asymmetry of MT effects in the brain is large enough to overshadow the CEST effects and that the so-called uniform-MT (uMT) method may be useful to reveal the genuine CEST contrast.

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