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Abstract #3307

Assessing Different Amide Proton Transfer (APT) Quantification Methods in Hyper-acute Stroke Patients

Yee Kai Tee 1 , George Harston 2 , Nicholas Blockley 3 , Thomas Okell 3 , Jacob Levman 1 , Martino Cellerini 4 , Fintan Sheerin 4 , Peter Jezzard 3 , James Kennedy 2 , Stephen Payne 1 , and Michael Chappell 1

1 Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxfordshire, United Kingdom, 3 FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxfordshire, United Kingdom, 4 Department of Neuroradiology, Oxford University Hospitals NHS Trust, Oxfordshire, United Kingdom

Amide proton transfer (APT) imaging is an emerging pH mapping MRI technique that has potential to identify salvageable tissue prior to irreversible infarction after stroke. However, the most widely used APT quantification method suffers from many confounding factors. In this study, 3 different APT quantification methods were studied on data acquired from healthy subjects and hyper-acute stroke patients (<6 hours of onset). It was found that a model-based approach, where the modified Bloch equations were fitted to measured data, was able to quantify the APT effect better than the widely used metric on both the healthy and patient data.

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