Abstract #3305
Usefulness of Three-Pool Lorentzian Model in Estimating APT effect and Parameterizing Spectral Curve Shape
HA-KYU JEONG 1 , SETH SMITH 2 , and HO SUNG KIM 3
1
Center for MR Research, Korea Basic Science
Institute, Cheongwon-Gun, Chungbuk, Korea,
2
Institute
of Imaging Science, Department of Radiology and
Radiological Sciences, Vanderbilt University, Nashville,
TN, United States,
3
Department
of Radiology, Research Institute of Radiology, Asan
Medical Center, University of Ulsan, College of
Medicine, Seoul, Korea
This preliminary study presents the results from human
brain tumor research using APT MR imaging. In this
study, we found that three-pool Lorentzian curve fit to
the original z-spectrum can provide not only the measure
of CEST effect, but also a useful parametric map in
delineating brain tumor lesions. In comparison to
Gd-enhanced T1w image, parameterized spectral curve
shape, similarly to non-enhanced T1w, provided decreased
lesion intensity, while APT effect presented increased
signal in the region of glioblastoma.
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