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Abstract #3304

Spillover, MT and R1 corrected chemical exchange saturation transfer (CEST) imaging in ischemic stroke

Hua Li 1 , Zhongliang Zu 1 , Moritz Zaiss 2 , Imad S. Khan 3 , Robert Singer 3 , Daniel F. Gochberg 1 , Peter Bachert 2 , John C. Gore 1 , and Junzhong Xu 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2 Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, BW, Germany, 3 Section of Neurosurgery, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States

CEST provides the ability to detect small solute pools through indirect measurement of the attenuated water signals. However, conventional quantification methods are affected by various confounding factors like MT, asymmetric MT effects, water longitudinal relaxation, and RF spillover. In the current study, the three-offset method and the 1/Z method were combined to correct the above influences and hence provide a more specific exchange rate weighted contrast in a rat model of ischemic stroke. The results demonstrate the applicability of the inverse Z-spectrum analysis for in vivo applications. The corrected APT shows more significant ischemic contrast. This study may provide insights into improved APT imaging.

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