Meeting Banner
Abstract #3300

Selection of irradiation parameters to minimize asymmetric magnetization transfer and NOE contributions in CEST

Tao Jin 1 and Seong-Gi Kim 1,2

1 Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Center for Neuroscience Imaging Research, Department of Biological Sciences, SKKU, Suwon, Korea

Magnetization transfer ratio asymmetry (MTR asym ) analysis of CEST studies removes direct water saturation and other symmetric non-CEST contributions. However, in vivo MTR asym is still confounded by asymmetric contributions, including magnetization transfer contrast from immobile macromolecules (MTC IM ) such as myelin, and nuclear Overhausser effects (NOE). Compared with the long-duration, low-power saturation of conventional CEST, it was recently reported that irradiation of shorter duration and higher power enhances sensitivity to amine and hydroxyl protons. In this work we report that higher irradiation power at shorter duration also provides another important advantage by minimizing contributions from MTC IM and NOE.

This abstract and the presentation materials are available to members only; a login is required.

Join Here