CEST imaging with phase cycled rectangular RF preparation pulse: analytical solution, simulation and phantom study

Chemical Exchange Saturation Transfer (CEST/APT) is a new contrast for clinical MRI. Because of SAR and RF amplifier limitation, continuous RF is not available in human clinical scanner. Although pulsed RF was used, the meaning of Z-spectrum is not clear. In this study, novel CEST preparation pulse with phase cycled 0.232ms rectangular shaped RF pulse was developed. Z-spectrum matched well between analytical solution and simulation. Z-spectrum of phantom was measured with 3T clinical scanner. B1/SAR was 4.5(ET)/1.0 (W/kg) and less. Simulation and phantom study show that phase cycled RF pulse can be used for CEST imaging.

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