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Abstract #3296

Rapid PROPELLER-CEST Encoding with Background Asymmetry Subtraction for Ultrafast Z-Spectrum Acquisition

Hoonjae Lee 1 , Chul-Ho Sohn 2 , and Jaeseok Park 1

1 Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea, 2 Department of Radiology, Seoul National University Hospital, Seoul, Korea

In this work we propose a novel, rapid propeller-CEST encoding with background asymmetry subtraction for ultrafast z-spectrum acquisition, wherein 1) off-resonant saturation and corresponding CEST encoding are performed along the angular (blade) direction over the entire k-space, 2) motion- and field-corrected z-spectrum data is synthesized using only a single k-space data (synthesize low frequency CEST signals while sharing high frequency signals), and 3) propeller-CEST encoding induced background asymmetry is subtracted from the z-spectrum. It is expected that the proposed method becomes a highly efficient alternative to conventional CEST for rapid z-spectrum acquisition and accurate CEST asymmetry analysis.

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