Abstract #3295
Ultrafast chemical exchange saturation transfer imaging based on spatiotemporal encoding
Miao Zhang 1 , Jianhua Lu 1 , Lin Chen 1 , Shuhui Cai 1 , Congbo Cai 1 , and Zhong Chen 1
1
Department of Electronic Science, Xiamen
University, Xiamen, Fujian, China
CEST MRI can detect low-concentration compounds with
exchangeable protons through saturation transfer to
water. This technique is generally time-consuming, as it
requires acquisition of saturation images at multiple
frequencies. EPI is the most common ultrafast MRI
approach, but it suffers from artifacts of
susceptibility heterogeneities and chemical shift
effect. The spatiotemporally encoded (SPEN) method
possesses higher built-in immunity to heterogeneity
while retaining the temporal and spatial performance of
EPI. In this abstract, SPEN is applied to improve the
acquisition efficiency and image quality of CEST. The
feasibility of CEST SPEN is demonstrated by experiments
on creatine solution phantoms.
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