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Abstract #3283

Fast 2D Harmonic Filtering of MRI phase; application to discriminating cerebral microbleeds in a multicenter clinical dataset

Takoua Kaaouana 1,2 , Ludovic de Rochefort 3 , Thomas Samaille 1,2 , Nathalie Thierry 4 , Genevieve Chene 4 , Christine Delmaire 5 , Didier Dormont 6 , and Marie Chupin 1

1 CRICM, UPMC UMR_S975, INSERM U975, CNRS UMR7225, ICM, INRIA, Paris, France, 2 CATI, Paris, France, 3 Univ. Paris-Sud, CNRS IR4M UMR8081, Orsay, France, 4 U897, INSERM, Bordeaux, France, 5 Neuroradiology, CHRU Roger Salengro, Lille, France, 6 Neuroradiology, CHRU pitie salpetriere, Paris, France

In MRI signal, phase is proportional to the local resonance frequency and therefore directly reflects magnetic field changes induced by local magnetic susceptibility sources. Composed of hemosiderin, cerebral microbleed can act as susceptibility sources and generate local dipole magnetic field. Here, we introduce a physically motivated fast 2D phase processing technique including unwrapping and harmonic filtering which yields the internal field. We demonstrate its applicability and robustness on multicenter 2D datasets acquired in standardized clinical setting to discriminate cerebral microbleeds.

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