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Abstract #3282

In-vivo Breast Microcalcification Detection via Susceptibility Weighted Imaging at 7T

Sergey Cheshkov 1,2 , Guillaume Gilbert 3 , Ivan Dimitrov 1,4 , Samantha By 5 , Joseph Rispoli 5 , Mary McDougall 5,6 , Steve Wright 5,6 , Stephen Seiler 2 , and Craig Malloy 1,2

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3 Philips Medical Systems, Montral, Qubec, Canada, 4 Philips Medical Systems, Cleaveland, OH, United States, 5 Biomedical Engineering, Texas A&M University, College Station, TX, United States, 6 Electrical Engineering, Texas A&M University, College Station, TX, United States

Pre-invasive cancer ductal carcinoma in situ (DCIS) may frequently be missed by the clinical dynamic contrast-enhanced MRI. DCIS has been shown to strongly associate with particular microcalcifications distributions and patterns. Susceptibility weighted imaging (SWI) has been proposed as a non-invasive radiation-free alternative to mammography for early detection of DCIS-associated breast microcalcifications (diamagnetic), providing better localization and 3D morphology. However, the desired high spatial resolution is not feasible on the 1.5T and 3T systems due to the long acquisition times. Benefiting from higher susceptibility effects and gain in SNR we demonstrate ultra-high resolution 7T SWI in vivo for calcification detection.

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