Abstract #3270
Assessment of Brain Iron Deficiency in Restless Legs Syndrome (RLS) Using Quantitative Susceptibility Mapping at 7T
Xu Li 1,2 , Hongjun Liu 1,3 , Richard Allen 4 , Christopher J Earley 4 , Richard Edden 1,2 , Peter B Barker 1,2 , Tiana Krum 4 , and Peter C.M. van Zijl 1,2
1
F.M. Kirby research center for functional
brain imaging, Kennedy Krieger Institute, Baltimore, MD,
United States,
2
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
3
Radiology,
Guangdong General Hospital, Guangzhou, Guangdong, China,
4
Neurology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States
Quantitative susceptibility mapping (QSM) at 7T was
utilized to assess possible brain iron deficiency in
restless legs syndrome (RLS) (AKA Willis Ekbom disease)
using the measured tissue magnetic susceptibility as an
iron index. Initial data collected on 14 RLS patients
and age-matched normal controls (n=5) showed decreased
magnetic susceptibility in RLS patients as compared to
controls in substantia nigra, red nucleus, dentate
nucleus, globus pallidus and the pulvinar nucleus of
thalamus. Among them the difference in dentate nucleus
was statistically significant (t test, one sided for
directional hypotheses, p<0.05), while there was a trend
toward differences in substantia nigra (p<0.12).
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