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Abstract #3269

Tract-based Atlas for Automatic Analysis of Magnetic Susceptibility in Human Brain White Matter

Xue Xiao 1,2 , Wei Li 2 , Kui Ying 3 , and Chunlei Liu 2,4

1 Department of Biomedical Engineering, Tsinghua University, Beijing, Beijing, China, 2 Brain Imaging & Analysis Center, Duke University, Durham, NC, United States, 3 Department of Engineering Physics, Tsinghua University, Beijing, China, 4 Department of Radiology, Duke University, NC, United States

The analysis of white matter in Quantitative Susceptibility Mapping (QSM) is complicated as white matter is heterogeneous due to different fiber. To utilize QSM in population based imaging analysis, a normalized brain atlas of QSM is needed. We developed such an atlas for automatic analysis of magnetic susceptibility in white matter and proposed a method for white matter analysis of the whole brain. The atlas was employed to investigate magnetic susceptibility anisotropy according to a sine-squared relationship with the fiber orientation. Results indicated a generally negative relation between magnetic susceptibility and contribution of myelin in white matter, and the fiber-track-based atlas was found to be more useful for anisotropy analysis of the white matter compared to region-based atlas.

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